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KMID : 0984720030350060434
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Infection and Chemotherapy
2003 Volume.35 No. 6 p.434 ~ p.438
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In vitro Antimicrobial Susceptibility of Carbapenems, Including Prepenem, Against Clinical Isolates in Korea
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Yoo Jin-Hong
Lee Dong-Gun
Kim Myung-Shin
Kang Jin-Han
Chun Hye-Sun
Song Min-Jin
Choi Su-Mi
Wie Seong-Heon
Kim Sang-Il
Choi Jung-Hyun
Shin Wan-Shik
Kang Moon-Won
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Abstract
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Objective : This study was performed to compare the in vitro antimicrobial activities of prepenem (PRPM) with those of imipenem (IMPM) and meropenem (MRPM) against several clinical isolates of Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Streptococcus pneumoniae. Methods : We tested the in vitro antimicrobial activities of PRPM, IMPM, and MRPM against total 300 clinical isolates of E. coli, K. pneumoniae, and P. aeruginosa and 134 chinical isolated of S. pneumoniae (41 penicillinsusceptible, 93 penicillinresistant strains) collected in 5 different university hospitals (March to June, 2002). According to NCCLS guidelines, MICs of PRPM, IMPM, MRPM, and/or ceftazidime were determined.
Results : MICgos of E. coli to IMPM, PRPM, and MRPM were 1, 1, and 0.125 pg/mL, respectively. Those of K. pneumoniae were 1, 0.5, and 0.125 Ng/mL, respectively. In case of P. aeruginosa, MlCgcs to IMPM, PRPM, MRPM, and ceftazidime were 16, 32, 8, and 64 ttg/mL, respectively. In penicillinsusceptible S. pneumoniae, MICqos to IMPM, PRPM, MRPM were 0.25, 0.25, 0.5 pg/mL, while those of penicillinnonsusceptible strains were 1, 1, and 2 Ng/mL, respectively. IMPM and PRPM showed similar pattern of distribution of MIC to various bacterial species.
Conclusion : E. coli, K. pneumoniae, and S. pneumonia were susceptible to PRPM, which had a pattern similar to IMPM. The antimicrobial activity of PRPM to P. aeruginosa was also comparable to that of IMPM.. PRPM could be potentially useful drugs for treatment of infections caused by E. coli, K. pneumoniae, P. aeruginosa and S. pneumoniae.
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KEYWORD
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Prepenem, Imipenem, Meropenem, Escherichia coli, Klebsiella pneumoniae, Pneumoniae, Pseudomonas aeruginosa, Streptococcus pneumoniae, Antimicrobial susceptibility
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